Kamagra Oral Jelly

Kamagra Oral Jelly
Kamagra Oral Jelly (Sildenafil Citrate)

Kamagra Oral Jelly is a sildenafil-based drug applied for the treatment of erectile dysfunction. It is released in an oral jelly form that is faster absorb into the blood. The effect is achieved faster - within 25 minutes. The effect lasts for 5-6 hours. It can be combined with low doses of alcohol. Sexual stimulation is required to keep a firm erection significant to complete sexual intercourse and get satisfaction.

Kamagra Oral Jelly is used for erectile dysfunction treatment. This drug restores reduced erectile function, increasing blood flow to the penile smooth muscles. The mechanism of action is based on the release of nitric oxide in the cavernous bodies at the time of sexual excitement. Free nitric oxide activates the guanylate cyclase enzyme, stimulating an increase in the level of cGMP. Consequently, it causes relaxation of the smooth muscle fibers of the corpora cavernosa and an increase in blood flow.

Nowadays, there are too many different analogs of classic Viagra. Kamagra Oral Jelly is one of the most effective means to fight erectile dysfunction in men. The main advantage this product has is reasonable price in comparison with branded drugs to treat the same disease. That’s why we offer our customers to buy generic Kamagra Oral Jelly from Kamagra UK at the cheap price.

Dosage and administration

One sachet is intended for single use only – open it and use all the contents. Apply strictly under medical supervision.

Kamagra should be taken approximately one hour before sexual intercourse. The recommended dose of Kamagra Oral Jelly is 50 mg and is taken before meals. Considering the effectiveness and tolerability, the drug dose can be increased to 100 mg or reduced to 25 mg.

The maximum recommended dose of jelly drug is 100 mg. The maximum recommended frequency of taking the drug is 1 time per day.

Side effects


Drug interactions

The effect of other drugs on Kamagra Oral Jelly (Sildenfil)

Sildenafil metabolism is predominantly caused by cytochrome P450 (CYP), isoforms 3A4 (main metabolic pathway) and 2C9 (secondary metabolic pathway). Therefore, inhibitors of these isoenzymes can affect sildenafil clearance.

Cimetidine (800 mg), a non-specific inhibitor of CYP, causes a 56% increase in plasma concentration of the drug while taking sildenafil (50 mg) in healthy volunteers.

Potent CYP3A4 inhibitors such as ketoconazole, itraconazole or mibefradil are considered to have a stronger effect. Clinical studies have shown a decrease in clearance of sildenafil in patients while taking it with CYP3A4 inhibitors. It should be expected that concomitant use of CYP3A4 inducers, such as rifampicin, may decrease the level of plasma sildenafil concentration.

A single dose of antacid (magnesium hydroxide/aluminum hydroxide) does not affect the bioavailability of sildenafil.

Kamagra Oral Jelly effect on other drugs

In vitro studies: the drug is a weak inhibitor of cytochrome P450 isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50> 150 mM). At maximum plasma concentrations of the drug, approximately 1 mM after administration at the recommended doses, it is unlikely that the drug will affect the clearance of the substrates of these isoenzymes.

In vivo studies: no significant interactions were recorded when taken concomitantly with tolbutamide (250 mg) or warfarin (40 mg), which are both metabolized by CYP2C9.

Kamagra Oral Jelly (50 mg) does not affect the increase in bleeding time caused by aspirin (150 mg).

Kamagra Oral Jelly (50 mg) does not enhance the hypotensive effect of alcohol in healthy volunteers with an average maximum blood alcohol level of 0.08%.

When Kamagra Oral Jelly 100 mg is taken simultaneously with amlodipine in hypertensive patients, an additional decrease in blood pressure in the supine position has a similar magnitude observed when taking only one drug in healthy volunteers.